Older women who have taken calcium-channel blockers for 10 years or longer have a higher risk of breast cancer than women prescribed other antihypertensives or who have never taken antihypertensives, research published this week suggests (JAMA Internal Medicine, online 5 August 2013).
The authors warn that more research is needed to confirm their results but say that: ?Quantification of the potential relationships between use of these medications and breast cancer risk has the potential to aid clinical decision making regarding selection of antihypertensive agents.?
Study participants were women aged 55 to 74 years with either invasive ductal carcinoma (IDC) or invasive lobular carcinoma (ILC) who lived within the greater Seattle metropolitan area in the US. These women were matched against randomly selected women without breast cancer. An increased risk of both IDC and ILC was observed for women who had taken calcium-channel blockers for at least 10 years compared with all other women in the study (odds ratio 2.4, 95 per cent confidence interval 1.2?4.9, OR 2.6, CI 1.3?5.3, respectively). Risk did not vary according to oestrogen receptor status.
Source: http://www.pjonline.com/news/longterm_calciumchannel_blocker_use_linked_with_breast_cancer
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